Lin J, Figuerado Y, Montgomery A, et al. - The efficacy and safety of ketamine vs parenteral haloperidol plus lorazepam for initial control of acute agitation were investigated via conducting a prospective, single-institution, randomized, open-label, real world, standard of care pilot study. Enrollment of 93 patients with combative agitation was done from January 15, 2018 to October 10, 2018. Participants were randomized to receive ketamine (4 mg/kg IM or 1 mg/kg IV) or haloperidol/lorazepam (haloperidol 5–10 mg IM or IV + lorazepam 1–2 mg IM or IV). Outcomes revealed significantly higher efficacy of ketamine vs haloperidol/lorazepam for initial control of acute agitation in patients with combative agitation. In addition, it was not linked with any significant adverse effects. .