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Efficacy of interleukin-6 in combination with D-dimer in predicting early poor postoperative prognosis after acute Stanford type A aortic dissection

Journal of Cardiothoracic Surgery Jul 22, 2020

Wu Q, Li J, Chen L, et al. - By analyzing data on 141 acute Stanford type A aortic dissection (ATAAD) patients, who had emergency surgery between January 2018 and December 2018, researchers focused on determining early poor postoperative prognosis in these patients as well as exploring the predictive impact of interleukin-6 (IL-6) together with D-dimer in the early poor postoperative prognosis following ATAAD. Group A included patients with good prognosis, and group B had patients with poor prognosis. In group A vs in B, lower preoperative IL-6 level as well as lower D-dimer was detected. As ascertained by the ROC curve, the cut-off points were preoperative IL-6 > 108 pg/mL (AUC = 0.901) and D-dimer > 14.0 μg/mL (AUC = 0.817). Experts found high predictive value of IL-6 > 108 pg/mL and D-dimer > 14.0 μg/mL for the evaluation of early poor postoperative prognosis following ATAAD. They also identified that IL-6 > 108 pg/mL together with D-dimer > 14.0 μg/mL afforded a higher predictive value.

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