Juo YY, et al. – Authors in this study examined the available literature and reported association between distal perfusion cannulae (DPC) and risk of limb ischemia. In adults treated with venoarterial extracorporeal membrane oxygenation (VA–ECMO), DPC placement seemed associated with a lower incidence of limb ischemia. Currently, they identified no consensus guidelines regarding indication for DPC placement. Given the association described in this analysis, future prospective trials are justified to establish a causal relationship and optimal technique for the use of DPC in patients treated with VA–ECMO.