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Efficacy of buffered hypertonic seawater in different phenotypes of chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery: A randomized double-blind study

American Journal of Otolaryngology - Head and Neck Medicine and Surgery May 30, 2020

Wang J, Shen L, Huang ZQ, et al. - Researchers conducted this randomized double-blind study to assess the effectiveness of seawater types in eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) and noneosinophilic CRSwNP (nonECRSwNP) after endoscopic sinus surgery (ESS). Participants in the study were patients with bilateral CRSwNP who had undergone ESS were blindly randomized to receive buffered hypertonic seawater (BHS) (n = 48) or physiological seawater (n = 45). All the patients reported significant improvements over time in SNOT-22 scores, VAS scores, and LKES. During CRSwNP's early postoperative care period, BHS has a better inhibitory effect on mucosal edema and crusting. Among all patients, there was a significant improvement in LEKS and SCT at 8 weeks in nonECRSwNP patients.

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