Researchers conducted a randomized, double-blinded, placebo-controlled trial with the aim to examine the efficacy of ablative fractional carbon dioxide (CO2) laser combined with autologous platelet-rich plasma (PRP) vs ablative fractional CO2 laser and placebo in the treatment of striae gravidarum (SG).

• The assigned treatment area (abdomen) in a total of 16 patients with SG was divided into two sides and was randomly assigned to the PRP side and the control side.

• Ablative fractional CO2 laser was administered to all patients; each laser procedure was immediately followed by administration of autologous PRP in the PRP side or plain normal saline solution (pNSS) as a placebo in the control side.

• Better clinical improvement and patients’ satisfaction were recorded in correlation with the combination of ablative fractional CO2 laser and autologous PRP when compared with ablative fractional CO2 laser and placebo, however, there appeared no statistically significance of the two outcome measures.

• Overall, outcomes suggest ablative fractional CO2 laser combined with autologous PRP as an effective treatment in SG.