Buitenwerf E, Osinga TE, Timmers HJLM, et al. - In the present randomized multicenter study, researchers sought to compare the effectiveness of pretreatment with either phenoxybenzamine or doxazosin, a selective and competitive α ₁-adrenergic receptor blocker, on the intraoperative hemodynamic stability during pheochromocytoma and sympathetic paraganglioma (PPGL) resection. This trial was performed between January 2012 and December 2017 at 9 sites in The Netherlands. The sample consisted of 134 patients with nonmetastatic PPGL. After 30 days, there had been no mortality. After preoperative treatment with either phenoxybenzamine or doxazosin, the duration of blood pressure outside the target range during resection of a PPGL was not different. Phenoxybenzamine was more effective in avoiding hemodynamic intraoperative instability, although it could not be determined if this has been associated with a better clinical outcome.