Pradeep AR, et al. - The effectiveness of metformin (MF) 1% gel as an adjunct to scaling and root planing (SRP) in the treatment of moderate and severe chronic periodontitis (CP) was examined in this study. A greater decrease was seen in probing depth (PD) and more clinical attachment level (CAL) gains with significant intrabony defect (IBD) depth reduction at sites treated with SRP plus locally delivered MF in patients with CP in both initial PD = 5 to 7 and >7 mm subgroups compared with placebo.