Chen D, Yang X, Liu X, et al. - Combination therapies may afford the best treatment for androgenetic alopecia (AGA) though the specific mechanism of their effect is not clear.

• The Bayesian network model was employed to analyze 49 RCTs with 3,133 patients and 6 interventions, to compare and rank a variety of treatments for AGA.

• Irrespective of based on hair density or hair diameter, the best treatment efficacy was shown by topical/systemic combined with adjunctive therapeutics (SMD: 40.11), followed by topical combined with systemic medical therapeutics (SMD: 36.41).

• Regarding hair density, treatment efficacy showed significant difference sequentially among topical medical therapeutics, systemic medical therapeutics, and adjunctive therapeutics relative to placebo.

• Combination therapies have recently emerged as significantly promising potential therapies.