Lee CH, Jin EM, Seo HS, et al. - In this prospective open-labeled trial, researchers tested the safety and effectiveness of treatment with a fractional 1,064-nm picosecond laser with a diffractive optic element for facial wrinkles and acne scars. The sample consisted of 22 patients with facial wrinkles or acne scars. At 3-week intervals, study participants received three laser treatments with a fractional 1,064-nm picosecond laser. The effectiveness and safety were assessed at every visit and 2 months after the final treatment (14 weeks from the first treatment session). Skin profilometry revealed significant improvements in the skin wrinkles, texture, depressions, and pores. The most common side effects were erythema, pruritus, and petechiae, which went away within 2~3 days. The fractional 1,064-nm picosecond laser is a therapeutic modality for skin rejuvenation that is both effective and safe.