Alkhodaidi ST, Al Hawsawi KA, Alkhudaidi IT, et al. - In this systematic review and meta‐analysis of randomized placebo‐controlled trials, researchers tested the safety and efficacy of topical clascoterone cream for the treatment of acne vulgaris. From inception to October 10, 2020, four databases were screened. Five clinical trials were included, containing 2,457 patients (1,357 and 1,100 patients, respectively, received clascoterone and placebo). The authors concluded that for the treatment of acne vulgaris, topical clascorterone cream is safe and effective.