Lin Z, et al. - This study sought to assess the efficacy and safety of pemetrexed and nedaplatin followed by pemetrexed maintenance therapy in advanced lung adenocarcinoma. Findings suggested the efficacy of combination chemotherapy based on pemetrexed and nedaplatin for the treatment of advanced lung adenocarcinoma with a high tolerance by patients. Pemetrexed maintenance therapy of advanced lung adenocarcinoma also proved safe and effective for the treatment of advanced lung adenocarcinoma following pemetrexed and nedaplatin combination chemotherapy.