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Efficacy and safety of paravertebral block vs intercostal nerve block in thoracic surgery and breast surgery: A systematic review and meta-analysis

PLoS Neglected Tropical Diseases Oct 08, 2020

Huan S, Deng Y, Wang J, et al. - Via performing a meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement issued in 2009, researchers sought to determine the analgesic efficacy and safety of paravertebral block (PVB) vs intercostal nerve block (INB) in thoracic surgery and breast surgery. Searching PubMed, Web of Science, Embase, and the Cochrane Library up to February 2020, they identified a total of 9 trials including 440 patients (PVB block: 222 patients; INB: 218 patients) for inclusion in this study. Outcomes suggest no significant difference in VAS for most of the time, rate of postoperative PONV, and rate of postoperative additional analgesic for patients undergoing thoracic surgery or breast surgery. However, significant difference was noted in VAS of non Chinese group at 1h and VAS of Chinese group at 24h in this analysis, which indicates PVB to be capable of providing a better analgesic effect. At the same time, lower consumption of morphine was noted in the PVB group vs the INB group in 48h with a significant difference.

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