Hill MD, Goyal M, Menon BK, et al. - A multicentre, double-blind, randomised controlled trial was designed to evaluate the efficacy and safety of nerinetide in human ischemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke. Researchers performed this study in 48 acute care hospitals in eight countries including individuals with acute ischaemic stroke due to large vessel occlusion within a 12 h treatment window. The study population consisted of 1,105 individuals who were randomized to receive nerinetide (n=549) or placebo (n=556). In individuals receiving alteplase, they observed the indication of treatment effect modification resulting in inhibition of treatment effect. The study founds equal serious adverse events between groups. Compared with individuals receiving placebo, nerinetide did not increase the proportion of individuals achieving good clinical outcomes after endovascular thrombectomy.