Khan SF, et al. - The authors aimed at comparing the relative efficacy and safety of mechanical compression devices (AutoPulse and LUCAS) with manual compression in patients with cardiac arrest undergoing cardiopulmonary resuscitation (CPR). For this Bayesian network meta-analysis, they selected seven randomized controlled trials (RCTs) using PubMed/Medline, EMBASE, and CENTRAL (Inception- 31 October 2017). Analysis of 12, 908 patients with cardiac arrest [AutoPulse (2, 608 patients); LUCAS (3, 308 patients) and manual compression (6, 992 patients)] revealed improved neurological recovery and survival in association with manual compression at 30 days or hospital discharge compared to AutoPulse. In addition, manual compression exhibited lesser risk of pneumothorax or hematoma formation compared to AutoPulse.