Moulis G, et al. - This cohort study was conducted to evaluate the effectiveness and the safety of biologics in patients with relapsing polychondritis (RP). Herein, the effectiveness of biologics for refractory RP was described. Experts noted a comparable persistence among biologic classes. The highest persistence was observed with adalimumab, among the TNF inhibitors. Depending upon biologics and organ involvement, differences in clinical response rates were observed. Findings demonstrated a low number of complete responses and concerns about the risk of ADRs, particularly infections.