Dawit G, et al. - In this systematic review and meta-analysis, researchers compared the safety and effectiveness of azithromycin and amoxicillin/clavulanate for the treatment of otitis media in children. Comparative randomized clinical trial studies between azithromycin and amoxicillin/clavulanate to treat otitis media in children published up to September 30, 2019, have been involved. Seven hundred fifty-one records were identified and 14 studies were eligible for analysis. For treating otitis media in children, azithromycin is equivalent to amoxicillin/clavulanate, but it is safer and more tolerable. Azithromycin may also be considered a first-line treatment for pediatric otitis media.