Foy BD, et al. - In this cluster-randomized trial, researchers tested the idea that mass administrations of ivermectin given repeatedly and often to village residents could lessen episodes of clinical malaria in children, be well tolerated, and result in minimal harms. Villages in Burkina Faso were asked to be a part of this single-blind (outcomes assessor), parallel-assignment, two-arm, cluster-randomized trial and were randomly assigned (1:1) to either the intervention or control group, with ultimately 1,447 enrolled into the intervention group and 1,265 into the control group. Cumulative malaria incidence was lower in the intervention group (648 episodes out of 327 children; estimated mean 2.00 episodes per child) vs the control group (647 episodes out of 263 children; 2.49 episodes per child. No adverse reactions were seen, and there was no variance between groups in risk of adverse events. Findings suggested that mass administration of ivermectin given repeatedly during the season of malaria transmission can lower episodes of malaria in children without significantly increasing harm in the population.