Ospina-Tascón GA, Hernandez G, Alvarez I, et al. - Researchers investigated if clinical outcomes in septic shock are influenced by a very early start of vasopressors (VP) even without completing the initial fluid loading. Using a prospectively obtained database, 337 patients with sepsis needing VP support for at least 6 h were initially chosen. Based on if norepinephrine was started or not within/before the next hour of the first resuscitative fluid load, the participants were categorized into very-early (VE-VPs) or delayed vasopressor start (D-VPs) groups. VE-VPs was identified to be associated with significant lower net fluid balances 8 and 24 h following VPs. A significant decrease in the risk of mortality was observed in relation to VE-VPs vs D-VPs, at day 28. Overall, the seeming safety of a very early start of vasopressor support was suggested, as well as its possible ability to limit the amount of fluids to resuscitate septic shock and to afford better clinical results was indicated in this study.