Gong J, et al. - Among patients receiving total parathyroidectomy with autotransplantation, this investigation was carried out to determine how ultrasound-guided bilateral cervical plexus block could impact general anesthesia, postoperative analgesia, and surgical outcomes. This analysis involved 48 American Society of Anesthesiologists III–IV patients with hyperparathyroidism secondary to kidney failure. Of participants, 24 were administered ultrasound-guided bilateral superficial and deep cervical plexus block combined with general anesthesia (group A), and 24 patients were given general anesthesia alone (group B). Sufentanil 2 μg/kg was delivered for postoperative patient-controlled intravenous analgesia. Findings demonstrated that both improved anesthesia management and better postoperative analgesia were effectively provided by ultrasound-guided bilateral superficial and deep cervical plexus block combined with general anesthesia for total parathyroidectomy with autotransplantation, and this strategy did not alter surgical outcomes.