Csifcsák G, et al. - In view of the wide application of transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) for improving symptoms of major depressive disorder (MDD), researchers here investigated the effects of different stimulation protocols in the entire frontal lobe in a large sample including patient data. In the left dorsolateral and bilateral medial PFC, effects were strongest. No considerable impact of depression-related neuroanatomy on stimulation effects was evident. They observed that 4×1 tDCS montages produce more localized, but weaker effects in target areas. Cortical targeting could be improved with simulation-based optimization of tDCS protocols.