Tominaga N, et al. - The impacts of tolvaptan addition to furosemide were assessed in normo- and hyponatremia patients with congestive heart failure (CHF) and chronic kidney disease (CKD) stages G3b-5. Findings showed that even in the very early treatment phase, a greater diuretic effect of tolvaptan added to furosemide was evident, compared with that of increased furosemide, even in normonatremia patients with CHF complicated by CKD stages G3b-5.