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Effects of thoracic radiotherapy timing and duration on progression-free survival in limited-stage small cell lung cancer

Cancer Medicine Jul 27, 2018

Zhao S, et al. - Researchers retrospectively examined 197 limited-stage small cell lung cancer (LS-SCLC) subjects receiving chemoradiotherapy (CRT) from 2000 to 2016 at Sun Yat-sen University Cancer Center. They wanted to assess prognostic values of thoracic radiotherapy (TRT) timing and duration on progression-free survival (PFS) in LS-SCLC and their dependence on TRT fractionation and clinicopathological characteristics. Particularly in patients receiving hyperfractionated TRT and etoposide-cisplatin chemotherapy, early-initiated TRT and short TRT had positive predictive value in LS-SCLC. in LS-SCLC, TRT fractionation was not an independent predictive factor.

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