Effects of tapering tumor necrosis factor inhibitor on the achievement of inactive disease in patients with axial spondyloarthritis: A nationwide cohort study
Arthritis Research & Therapy Jul 10, 2019
Park JW, et al. - In patients with axial spondyloarthritis (axSpA), researchers examined the connection between the extent of tapering tumor necrosis factor inhibitor (TNFi) and the probability of achieving inactive disease. In a nationwide observational cohort, they evaluated 1575 one-year follow-up interval data of 776 patients. Using the generalized estimating equation, the impacts of TNFi tapering on the outcome were analyzed. According to findings, 91.1% of the patients exhibited a high disease activity (ASDAS-CRP ≥ 2.1) at the baseline visit. Findings suggested that mild TNFi tapering has comparable efficacy with the standard-dose treatment for Ankylosing Spondylitis Disease Activity Score-inactive disease achievement in axSpA patients.
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