Shen H, et al. - Experts evaluated the impacts of statin therapy in chronic kidney disease (CKD) + coronary artery disease (CAD) patients. Cardiovascular events and mortality rates of the CKD patients with concomitant CAD were dramatically reduced with long-term statin therapy. Good prognosis was seen in the CKD-only patients and they did not appear to require statin treatment.

Methods

• Authors compared the impacts of long-term statin therapy (follow-up time 4 years) in terms of cardiovascular events, all-cause death, and cardiac death among 254 CKD patients with or without CAD.

Results

• Findings suggested that compared with CKD patients, long-term statin therapy was much more effective in the CKD + CAD patients.
• As per the data, in the CAD + CKD patients, long-term statins showed a 22.2% reduction in the CVs rate (P=0.012).
• Long-term statins had significant treatment effects on the CAD + CKD patients (reduction of about 28.1% in mortality rates, P < 0.001) with regard to the all-cause and cardiac deaths.
• In contrast, no significant influence on the clinical outcomes of the CKD-only patients was exerted by long-term statin therapy.