Hepp T, Othman A, Liebgott A, et al. - A retrospective study was conducted to investigate the potential impact of CT dose variation on radiomic features in vivo applying simulated contrast-enhanced CT dose reduction in patients with non-small lung cell cancer (NSCLC). Researchers recruited 69 individuals (25 females, 44 males, median age 66 years) with histologically tested NSCLC who experienced a whole contrast-enhanced body FDG-PET/CT for primary staging. They applied an algorithm to simulate low-dose CT images based on a noise model derived from phantom experiments. Further, they explored Radiomic feature extraction applying the PyRadiomics toolbox. It was observed that dose-dependent deviations of feature values indicated a monotonous elevate or reduce with decreasing dose levels. The observation demonstrated indicative differences between the dose levels in 91% of features.