Kocatürk E, Al-Ahmad M, Krause K, et al. - Researchers aimed at determining the course and features of chronic urticaria (CU) during and after pregnancy in PREG-CU, an international, multicentre study of the Urticaria Centers of Reference and Excellence (UCARE) network. Among 288 CU patients from 13 countries with a total of 288 pregnancies (mean age at pregnancy: 32.1 ± 6.1 years, duration of CU: 84.9 ±74.5 months; CSU 66.9%, CSU+CIndU 20.3%, CIndU 12.8%), 51.1% of patients rated their CU as improved, 28.9% as worse, and 20.0% as unchanged during pregnancy. For worsening of CU during pregnancy, the risk factors were having mild disease and no angioedema before pregnancy, not taking treatment before pregnancy, CIndU, CU worsening during a previous pregnancy, treatment during pregnancy and stress as a driver of exacerbations. After giving birth, 43.8% of CU patients had unchanged urticaria disease activity, whereas 37.4% and 18.1% experienced worsening and improvement, respectively. Results thereby demonstrate that pregnancy has a complex impact on the course of CU and may aid to better counsel patients who want to become pregnant and to manage CU during pregnancy.