Effects of polycyclic aromatic hydrocarbons exposure combining high-risk human papillomavirus infection on cervical intraepithelial neoplasia: Based on population study in Shanxi Province, China
International Journal of Cancer Jul 18, 2019
Li X, et al. - In a community population in Shanxi Province, China of 2,285 women, researchers determined the impacts of polycyclic aromatic hydrocarbons (PAHs) exposure on cervical cancer by combining high-risk human papillomavirus (HR-HPV) infection on cervical intraepithelial neoplasia (CIN). Using flow-through hybridization technology, they detected HR-HPV genotypes. Via high performance liquid chromatography, they detected 1-hydroxypyrene. An increased risk of CIN2/3 was reported, in unconditional logistic regression analysis, relative to HR-HPV infection, HPV16 infection, HPV58 infection, and high PAHs exposure, displaying an increasing trend with the severity of cervical lesions. In this study, an increased CIN risk could be seen in relation to high exposure to PAHs. In particular, the risk was stronger when combining with HR-HPV infection.
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