Wang SM, et al. - Researchers report the impacts of nutrition intervention on total and cancer mortality assessed during a 25-year post-trial follow up of the Linxian Nutrition Intervention Trial which was run in China from 1986 to 1991 and included 29,584 residents age 40 to 69 years. Participants were assigned to daily supplementations based on a factorial design: Factors A (retinol/zinc), B (riboflavin/niacin), C (vitamin C/molybdenum), and/or D (selenium/vitamin E/beta-carotene), or placebo. They found that even in a nutritionally deprived population, a meaningful effect of multiyear nutrition intervention on mortality was unlikely to be seen even a decade after supplementation ended.