Feng Y, et al. - Researchers investigated the efficacy of non-invasive brain stimulation (NIBS) techniques such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation in modifying headache intensity and frequency of headache attacks in patients suffering from migraine. Searching 5 databases—PubMed, EMBASE, Web of Science, Cochrane Library, and Scopus—they included 9 randomized controlled trials with 276 participants in total (experimental group = 149; control group = 127) in this review. As per meta-analysis of excitatory primary motor cortex (M1) stimulation, patients with migraine showed significant reduction effects in headache intensity with a large effect size. Meta-analysis of excitatory M1 stimulation revealed significant reduction effects on the frequency of headache attacks in patients with migraine, with a large effect size. Excitatory dorsolateral prefrontal cortex stimulation had a significant effect on the headache intensity with a large effect size but not on the frequency of headache attacks in patients with migraine. These findings support the possible efficacy of excitatory NIBS of the M1 to reduce headache intensity and the frequency of headache attacks in patients with migraine.