Tavazzi E, et al. - Authors sought to evaluate the functional and structural brain changes induced by gait rehabilitation in multiple sclerosis (MS). They obtained several clinical measures, including 2-min walk test (2MWT), dynamic gait index (DGI), and Berg balance scale (BBS). Experts noted a significant improvement of 2MWT, DGI, and BBS scores along with a reduced extent of the widespread activation associated with the motor task at the functional MRI (fMRI) and an elevated functional connectivity in the precentral and post-central gyrus, bilaterally. None of these changes were maintained in the long term. Results demonstrated that motor rehabilitation had a short-term beneficial impact on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.