Tsai WC, et al. - Given elevated fibroblast growth factor-23 (FGF23) levels increase the risk of cardiovascular diseases in patients with chronic kidney disease (CKD), researchers herein compared the impacts of different dietary interventions, lower vs higher phosphate levels, on FGF23 in patients with CKD. They found that in patients with moderately decreased kidney function, short-term dietary phosphate restriction tended to attenuate FGF23 levels. Also, it was noted that the FGF23-lowering impacts tended to be more prominent when measured with the intact FGF23 assay.