Miñambres I, et al. - A systematic review was performed following PRISMA guidelines to synthesize the effects of inositol on glucose homeostasis in different clinical conditions. Researchers searched Web of Science and Medline for randomized controlled trials (RCTs) that addressed supplementation with compounds of the inositol family in humans and assessed their effects on glucose homeostasis. Findings revealed that inositol supplementation decreases blood glucose through an improvement in insulin sensitivity that was independent of weight. Among published trials, assessment of adverse effects was scarce and should be fully addressed before considering inositol as a therapeutic agent for glucose-related outcomes. In addition, the characterization of the subjects achieving benefit from the intervention and the formulations to be used should be known.