Lee CC, et al. - The changes in 4 diffusion tensor imaging parameters in the white matter of patients with early-stage Alzheimer’s disease (AD) were investigated. Furthermore, the study aimed to investigate their associations with homocysteine level and examine the clinical significance of the diffusion tensor imaging parameters and homocysteine level in correlation analysis with cognitive test scores. Homocysteine levels were associated with renal dysfunction and decreased levels of vitamin B12 and folate in these patients with AD. In cross-sectional observations, as they seemed to be associated with impaired white matter (WM) microstructural integrity and modulated cognitive performance, the clinicians recommended clinical attention to these patients.