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Effects of high neuromuscular blocking agent dose on postoperative respiratory complications in infants and children

Acta Anaesthesiologica Scandinavica Sep 24, 2019

Scheffenbichler FT, Rudolph MI, Friedrich S, et al. - In infants and children, researchers explored the connection between neuromuscular blocking agent dose and postoperative respiratory complications. To investigate the impacts of neuromuscular blocking agent dose on postoperative respiratory complications (primary endpoint) and secondary endpoints, data from 6,507 general anaesthetics provided to children ≤ 10 years undergoing surgery were analysed. According to findings, postoperative respiratory complications were correlated with a high dose of neuromuscular blocking agents. Subcohorts of paediatric patients who are especially vulnerable to the respiratory side-effects of neuromuscular blocking agents were identified: infants, paediatric patients undergoing surgeries of short duration, and those with a high ASA risk score.
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