Liu T, et al. - Researchers sought to determine the indications for high-flow nasal cannula oxygen (HFNC) therapy in patients with hypoxemia during ventilator weaning. They also inquired the predictors of reintubation when treatment fails. They used the Medical Information Mart for Intensive Care IV database to select the participants. Patients were allocated to the treatment group or control group based on if they were undergoing HFNC or non-invasive ventilation (NIV) post-extubation. In terms of 28-day reintubation rate or 28-day mortality, no significant differences were evident between the two groups with moderate or severe hypoxemia. According to findings, no inferior therapeutic impact was conferred by HFNC therapy when compared with that of NIV, even on patients with oxygenation index from 160 to 180 mmHg when weaning from ventilator. HR/SpO ₂ , relative to ROX index (ratio of SpO ₂ /FiO ₂ to respiratory rate), was more early and precise in predicting HFNC failure.