Izzi-Engbeaya C, Jones S, Crustna Y, et al. - By performing this single-blind, randomized, placebo-controlled crossover study, researchers determined how the reproductive axis in humans may be influenced by glucagon-like peptide-1 (GLP-1) administration. This inquiry involved 18 healthy men (mean age 24.7 ± 0.1years, mean BMI 22.1 ± 0.4kg/m²). The study intervention included an 8-hour intravenous infusion of 0.8pmol/kg/min GLP-1 or rate-matched vehicle infusion. During vehicle and GLP-1 administration, no significant difference was evident in the number of luteinizing hormone (LH) pulses, LH area under the curve (AUC), follicle stimulating hormone AUC and testosterone AUC. A significant decrease in food consumption was brought about by GLP-1. Compared with the animal literature, findings revealed no influence of acute GLP-1 administration on reproductive hormone secretion in healthy men.