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Effects of gestational age on early survivability in neonates with Hypoplastic Left Heart Syndrome

American Journal of Cardiology Jul 28, 2018

Mechak JT, et al. - Researchers investigated the effect of gestational age (GA) on survival to stage 1 palliation surgery and hospital discharge among 1,913 neonates with hypoplastic left heart syndrome (HLHS) born at or transferred to a Vermont Oxford Network (VON) expanded member hospital in the US from 2009 to 2014. They analyzed data obtained from these subjects and developed risk models controlling for common confounders to determine the relative risk of GA on the observed outcomes. GA was identified as an independent risk factor for survival to stage 1 palliation surgery and survival to hospital discharge. However, in infants born between 34-37 weeks gestation, no significant difference in survival to hospital discharge was evident.

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