Roos VH, Mangas-Sanjuan C, Rodriguez-Girondo M, et al. - Because guidelines recommend that individuals with familial colorectal cancer (FCC) undergo colonoscopy surveillance vs average-risk screening—yet these recommendations vary widely—researchers performed a systematic review and meta-analysis to analyze the impact of family history on relative and absolute risks for colorectal cancer (CRC). A total of 42 eligible case-control and 20 cohort studies were identified. According to findings, the cumulative absolute risks for CRC at 85 years were 4.8% for persons with 1 first-degree relative (FDR) with CRC, 8.2% for persons with ≥ 2 FDRs, and 11% for persons with FDR diagnosed with CRC at an age younger than 50 years. Furthermore, the RR of CRC among FDRs was found to be lower than previously expected, particularly based on cohort studies. Overall, the number of CRC relatives and their age at diagnosis were found to affect risk estimates. For high-risk groups, intensified colonoscopy surveillance strategies should be considered, suggested the investigators.