Liao X, Zhou Z, Zhou M, et al. - In this meta-analysis with 4,913 eligible participants, researchers compared endovascular cooling (EC) vs surface cooling (SC) with respect to effectiveness, stability, and safety of mild therapeutic hypothermia induced by these cooling methods, as well as determined its influence on ICU, survival rate, and neurological function integrity among adult cardiac arrest patients. Outcomes during target temperature management as well as ICU stay, survival rate, and neurological functional integrity were incorporated in results. In terms of the time from the start of cardiac arrest to achieve the target temperature, no significant difference was evident between the two cooling methods applied to adult patients receiving cardiopulmonary resuscitation, but EC afforded faster cooling rate and more stable cooling process, which resulted in shortening of patients’ ICU hospitalization time as well as led to good neurological prognosis in more patients, compared with SC. Meanwhile, although EC vs ArcticSun yielded no significantly distinct patient outcomes, EC resulted in improved rates of neurologically intact survival.