Tan W, et al. - Among patients undergoing laparoscopic gastrointestinal surgery, whether an effective attenuation in the pneumoperitoneum-associated hemodynamic alterations and the release of vasopressin could be brought about by different doses of magnesium sulfate, was determined in this study. Researchers randomized 69 patients undergoing laparoscopic partial gastrectomy to group L; delivered magnesium sulfate 30 mg/kg loading dose and 15 mg/kg/h continuous maintenance infusion for 1 h, group H; administered magnesium sulfate 50 mg/kg followed by 30 mg/kg/h for 1 h, or group S (control group) in which same volume 0.9% saline infusion was delivered, immediately prior to the induction of pneumoperitoneum. The difference in systemic vascular resistance between distinct groups was the primary outcome. Findings revealed the safety as well as the effectiveness of magnesium sulfate in attenuating the pneumoperitoneum-associated hemodynamic instability during gastrointestinal laparoscopy, as well as its ability to improve postoperative pain at serum magnesium levels above 2 mmol/L.