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Effects of curative-intent lung cancer therapy on functional exercise capacity and patient-reported outcomes

Supportive Care in Cancer Aug 28, 2020

Ha D, Ries AL, Lippman SM, et al. - Researchers here examined how curative-intent lung cancer treatment affects functional exercise capacity (EC) as well as patient-reported outcomes (PROs). In one of the first prospective, observational cohort studies on this subject, they included 35 patients with stage I–IIIA lung cancer undergoing curative-intent therapy. Findings revealed correlation of treatment with a clinically meaningful and borderline-significant decline in functional EC, clinically meaningful and statistically significant greater dyspnea and fatigue; there was no clinically meaningful or statistically significant change in cancer-specific quality of life at 1 to 3 months following treatment. They emphasize focusing on treating dyspnea, fatigue, and/or improving functional EC in interventions to decrease treatment-related morbidities and improve lung cancer survival.

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