Park S, Choi AY, Park E, et al. - Researchers examined how continuous ketamine infusion affects hemodynamics and mortality rate among critically ill pediatric patients. From a tertiary pediatric intensive care unit (PICU), they assessed 240 patients who used continuous sedation for 24 hours or more and 82 patients who used continuous ketamine. Following ketamine infusion, patients had a decrease in heart rates (138 vs 135 beat/minute) and respiratory rates (31 vs 25 respiration/minute), but no change in blood pressure (99.9 vs 101.1 mm Hg) and vasogenic medications. They did not identify continuous ketamine as a significant risk factor for mortality. Hence, use of continous ketamine in PICU could be undertaken without causing hemodynamic instability.