Serraino GF, et al. - The proposition examined here was that the use of near-infrared spectroscopy (NIRS) cerebral oximetry led to reductions in cerebral injury (neurocognitive function, serum biomarkers), injury to other organs with the inclusion of heart and brain, transfusion rates, mortality and resource use. The findings did not support the hypotheses that cerebral NIRS-based algorithms displayed clinical benefits in patients undergoing cardiac surgery.