Shiraishi N, et al. - Researchers sought to determine the association between the onset of rocuronium-induced neuromuscular block and arterial pressure-based cardiac output (CO) in elderly patients. In study participants ie, elderly patients aged 65–83 years, anesthesia induction was followed by acceleromyographical assessment of contractions of the adductor pollicis muscle to ulnar nerve train-of-four stimulation. In these subjects, 1 mg/kg rocuronium was administered following CO measurement. They assessed the correlation between onset of rocuronium action and CO. They found that CO had an impact on the onset of action of rocuronium in the elderly. A statistically significant inverse correlation was found between the onset time of rocuronium and CO.