Volodarsky-Perel A, et al. - Researchers performed this retrospective cohort study to examine how the stage and grade of malignancy influence the fertility preservation outcome in females. Data of all fertility preservation treatment cycles among women with cancer at the reproductive unit of the McGill University Health Centre in the period from 2008 to 2017 were evaluated. They analyzed a total of 147 patients in the final analysis. A higher dose of gonadotropin was required for women with high-stage cancer (n = 64) required that those with low-stage cancer (n = 83). The two groups were similar regarding the number of retrieved mature oocytes (9 (7–13) vs 8 (5–12)) and vitrified oocytes (10 (7–15) vs 10 (7–13)). However, the low-stage group displayed higher fertilization rate (82.7% vs 71.5%) and the number of vitrified embryos (6.2 ± 3.2 vs 4.3 ± 2.1) in cycles where fertilization of all retrieved oocytes was performed. The multivariate logistical analysis suggested a significant association between low-grade cancer and retrieval of over 10 mature oocytes.