Volodarsky-Perel A, et al. - In this retrospective cohort study, researchers investigated the influence of the stage and grade of malignancy on fertility preservation outcome in females. Data of all fertility preservation treatment cycles among women with cancer was evaluated at the reproductive unit of the McGill University Health Centre from 2008 to 2017. Researchers included patients aged 18-38 years, had first stimulation cycle, GnRH-antagonist protocol, and early follicular phase stimulation start. They included only one stimulation cycle per patient. They analyzed a total of 147 patients in the final analysis, which revealed a lower number of retrieved mature oocytes and cryopreserved embryos among patients with high-grade cancer. This suggests a negative effect of cancer grade on the fertility preservation outcome and the ovarian stimulation response.