Hall E, et al. - Researchers investigated non-cancer outcomes, including quality of life (QOL), menopausal symptoms and sexual functioning among female BRCA mutation carriers who had bilateral salpingo-oophorectomy (BSO). Using medical history questionnaire, Menopause-Specific Quality of Life Intervention questionnaire and Sexual Activity Questionnaire, they performed assessments in BRCA mutation carriers who elected to undergo a BSO. These assessments were performed both prior to surgery and then again approximately one and three years following surgery. According to findings, a significant worsening of menopausal symptoms and a decline in sexual functioning were experienced by BRCA mutation carriers at 3.5 years after oophorectomy. These were specifically seen among those who had surgery prior to natural menopause. Not all, but some effects were mitigated by using HRT. Overall, no reduced QOL was seen among women who were premenopausal at surgery.