Reig A, et al. - This study was performed to investigate the effects of the combined treatment with ursodeoxycholic acid (UDCA) and bezafibrate on a long-term basis. The long-term treatment with UDCA and bezafibrate resulted in an excellent response and was correlated with a complete or partial itching relief. Among patients with advanced disease who remained at risk for developing severe events, incomplete alkaline phosphatase (ALP) normalization was observed. In patients with lower fibrosis and severity of cholestasis, the combined treatment was mainly effective.