Huang HI, et al. - Researchers conducted this investigation to explore the connections between malignant transformation of oral potentially malignant disorders (OPMDs), oral cancer development and prognosis, and apurinic/apyrimidinic endonuclease 1 (APE1) functional polymorphisms. According to follow-up and survival analysis, the APE1 Asp148Glu polymorphisms were significantly correlated with a high hazard ratio for malignant OPMD transformation and low overall survival in oral cancer patients. However, in the case-control study and logistic regression analysis, APE1 polymorphisms did not significantly correlate with the development of oral cancer. According to findings, APE1 Asp148Glu polymorphisms can play an indirect role in increasing the rate of malignant transformation of OPMD and decreasing overall survival in patients with oral cancer.