Voineskos AN, Mulsant BH, Dickie EW, et al. - This study intended to evaluate the impacts of antipsychotics on brain structure in humans. Researchers designed a prespecified secondary analysis of a double-blind, randomized, placebo-controlled trial over 36 weeks at 5 academic centers. They included all individuals, aged 18 to 85 years, from the multicenter Study of the Pharmacotherapy of Psychotic Depression II (STOP-PD II). This study included a total of 88 individuals (age range, 18-85 years) (a baseline scan); 75 completed a follow-up scan, of which 72 (32 men and 40 women) were useable for final analyses. The results showed that antipsychotic medication was shown to change brain structure. It is demonstrated that this information is important for prescribing in psychiatric conditions where alternatives are present. Nevertheless, the adverse impacts of relapse on brain structure help antipsychotic treatment during active illness.